Research
Daily Field Notes on emerging psychedelic clinical trials and pharmacology — N,N-DMT, 5-MeO-DMT, ayahuasca, ibogaine, and related tryptamines. Coverage of preprints, peer-reviewed papers from PubMed, and the major research centres (Imperial, MAPS, Beckley, Cybin, Usona). Receptor pharmacology, biased agonism, deuterated analogues, and the translation of psychedelic compounds from bench to clinic. Independent, evidence-led, primary sources cited.
DMT vs Ketamine: Equal on Depression, DMT Wins on Anxiety
De Sousa-Silva et al. compare DMT to S-ketamine in helpless mice: matched on depression, but DMT also produces anxiolysis. From the Natal ayahuasca group.
Beckley Psytech's BPL-003: 5-MeO-DMT Without SSRI Washout
Beckley Psytech's BPL-003 trial gave intranasal 5-MeO-DMT to depressed patients still on SSRIs — no washout required. First proof-of-concept of its kind.
Endogenous DMT: Not in Serotonin Terminals — Palner et al
Palner et al. find DMT is neither synthesised nor stored in serotonin terminals (rat). The endogenous DMT hypothesis narrows — but is not entirely buried.
5-HT1A Blockade Potentiates DMT: Zahid, Strassman et al.
Zahid, Strassman et al. show that blocking 5-HT1A receptors potentiates DMT's subjective effects — first human evidence that the 5-HT1A 'brake' is real.
DMT for Stroke: Exeter Knockout Data Challenges Sigma-1 Story
Exeter data shows DMT inhibits stroke-related spreading depolarisations more effectively in sigma-1 knockout mice — challenging the prevailing mechanism.
DMT research: Top recent findings from 34 papers.
DMT research: top findings and the state of play A synthesis of 34 recent papers on DMT and its close analogue 5-MeO-DMT, written for a non-specialist professional audience. DMT is a small naturally occurring molecule, structurally similar to the neurotransmitter serotonin, that produ
DMT for Substance Misuse: An Exeter/Imperial Meta-Analysis
A systematic review and meta-analysis examining whether DMT-based interventions can shift the needle on substance misuse has appeared in the Journal of Psychopharmacology, authored by a team spanning the University of Exeter and Imperial College London
SPL028 Cybin 2024
What a careful read of the SPL028 Phase 1 synopsis tells us about deuteration....