Section
ARDMT Field Notes
DMT vs Ketamine: Equal on Depression, DMT Wins on Anxiety
De Sousa-Silva et al. compare DMT to S-ketamine in helpless mice: matched on depression, but DMT also produces anxiolysis. From the Natal ayahuasca group.
Beckley Psytech's BPL-003: 5-MeO-DMT Without SSRI Washout
Beckley Psytech's BPL-003 trial gave intranasal 5-MeO-DMT to depressed patients still on SSRIs — no washout required. First proof-of-concept of its kind.
Endogenous DMT: Not in Serotonin Terminals — Palner et al
Palner et al. find DMT is neither synthesised nor stored in serotonin terminals (rat). The endogenous DMT hypothesis narrows — but is not entirely buried.
5-HT1A Blockade Potentiates DMT: Zahid, Strassman et al.
Zahid, Strassman et al. show that blocking 5-HT1A receptors potentiates DMT's subjective effects — first human evidence that the 5-HT1A 'brake' is real.
DMT for Stroke: Exeter Knockout Data Challenges Sigma-1 Story
Exeter data shows DMT inhibits stroke-related spreading depolarisations more effectively in sigma-1 knockout mice — challenging the prevailing mechanism.
DMT for Substance Misuse: An Exeter/Imperial Meta-Analysis
A systematic review and meta-analysis examining whether DMT-based interventions can shift the needle on substance misuse has appeared in the Journal of Psychopharmacology, authored by a team spanning the University of Exeter and Imperial College London