Section
ARDMT Field Notes
DMT for Parkinson's: Sigma-1 Neuroprotection in a 6-OHDA Model
Calleja-Conde and Morales-García extend the Madrid group's DMT–sigma-1 neuroprotection case into a Parkinson's model. Suggestive, not yet definitive — but building.
DMT shows neuroprotective effects in a Parkinson's rat model — a Madrid group extends its σ1R hypothesis
Could DMT protect dopamine neurons? A new preclinical study from Madrid says yes — at least in rats. Here's what the data show, what the σ1R–NRF2 mechanism implies, and why translation to human Parkinson's remains an open question.
Ayahuasca Alkaloids in Hair: A New Long-Window Exposure Biomarker
Santos et al. validate a hair-analysis method for DMT and β-carbolines — turning a single strand into a months-long record of ayahuasca exposure.
Szára's 1956 self-experiment: the Budapest dose that launched DMT research
Cold War Hungary, 1956: Stephen Szára couldn't get LSD, so he made DMT and dosed himself. Modern psychedelic research began that afternoon.
Can Halogenated DMT Analogues Be Non-Hallucinogenic? G-Protein Bias
A preprint shows 2-chloro and 2-bromo DMT analogues display G-protein bias at 5-HT2A — relevant to the hunt for non-hallucinogenic psychedelics.
Long-Term Ayahuasca: Personality Shifts, Cognition Intact (Bouso)
Bouso compares chronic ayahuasca users with cannabis users and non-users: personality differs across groups, cognitive function is spared.
Ayahuasca vs Meditation: Two Routes to Ego Dissolution?
Arqueros et al. compare hypo-egoic features in ayahuasca users and long-term meditators — testing whether pharmacology and contemplation reach the same place.
2-Halogenated Tryptamines: How One Atom Reshapes DMT Pharmacology
Von Salm, McCorvy and Baumann profile 2-halogenated tryptamines: halogen choice at the 2-position reshapes 5-HT receptor selectivity and signalling bias.
UCL's UNITy Trial: Can DMT Disrupt Alcohol Memory Reconsolidation?
UCL's UNITy trial pairs IV DMT with alcohol memory reactivation in heavy drinkers — testing whether DMT plasticity can rewrite addiction memories.
DMT EEG: Alpha Power Outperforms Lempel-Ziv Complexity (Timmermann)
Timmermann et al. test EEG correlates of the DMT experience: alpha power outperforms Lempel-Ziv complexity, the entropic-brain hypothesis's signature.
DMT and Ayahuasca Clinical Trials: 2026 Pipeline Scoping Review
Stojanović et al. map every registered DMT and ayahuasca trial — and quantify how much of the field never publishes its results. Useful cartography.
5-MeO-DMT Brain Connectivity in Awake Rats: Sex and Dose Effects
Cavallaro et al. (Ferris lab) map 5-MeO-DMT brain connectivity in awake rats — distinct dose and sex effects emerge in limbic and prefrontal circuits.