Author
Stephen Page
Writer on DMT, ayahuasca, iboga and tryptamine research. LLB; incoming MSc in Psychedelics: Mind, Medicine and Culture, University of Exeter (2026)
ARDMT Field Notes
Long-Term Ayahuasca: Personality Shifts, Cognition Intact (Bouso)
Bouso compares chronic ayahuasca users with cannabis users and non-users: personality differs across groups, cognitive function is spared.
ARDMT Field Notes
Ayahuasca vs Meditation: Two Routes to Ego Dissolution?
Arqueros et al. compare hypo-egoic features in ayahuasca users and long-term meditators — testing whether pharmacology and contemplation reach the same place.
ARDMT Field Notes
2-Halogenated Tryptamines: How One Atom Reshapes DMT Pharmacology
Von Salm, McCorvy and Baumann profile 2-halogenated tryptamines: halogen choice at the 2-position reshapes 5-HT receptor selectivity and signalling bias.
ARDMT Field Notes
UCL's UNITy Trial: Can DMT Disrupt Alcohol Memory Reconsolidation?
UCL's UNITy trial pairs IV DMT with alcohol memory reactivation in heavy drinkers — testing whether DMT plasticity can rewrite addiction memories.
ARDMT Field Notes
DMT EEG: Alpha Power Outperforms Lempel-Ziv Complexity (Timmermann)
Timmermann et al. test EEG correlates of the DMT experience: alpha power outperforms Lempel-Ziv complexity, the entropic-brain hypothesis's signature.
ARDMT Field Notes
DMT and Ayahuasca Clinical Trials: 2026 Pipeline Scoping Review
Stojanović et al. map every registered DMT and ayahuasca trial — and quantify how much of the field never publishes its results. Useful cartography.
Research
5-MeO-DMT Brain Connectivity in Awake Rats: Sex and Dose Effects
Cavallaro et al. (Ferris lab) map 5-MeO-DMT brain connectivity in awake rats — distinct dose and sex effects emerge in limbic and prefrontal circuits.
Research
DMT vs Ketamine: Equal on Depression, DMT Wins on Anxiety
De Sousa-Silva et al. compare DMT to S-ketamine in helpless mice: matched on depression, but DMT also produces anxiolysis. From the Natal ayahuasca group.
Research
Beckley Psytech's BPL-003: 5-MeO-DMT Without SSRI Washout
Beckley Psytech's BPL-003 trial gave intranasal 5-MeO-DMT to depressed patients still on SSRIs — no washout required. First proof-of-concept of its kind.
Research
Endogenous DMT: Not in Serotonin Terminals — Palner et al
Palner et al. find DMT is neither synthesised nor stored in serotonin terminals (rat). The endogenous DMT hypothesis narrows — but is not entirely buried.
Research
5-HT1A Blockade Potentiates DMT: Zahid, Strassman et al.
Zahid, Strassman et al. show that blocking 5-HT1A receptors potentiates DMT's subjective effects — first human evidence that the 5-HT1A 'brake' is real.
ARDMT Field Notes
DMT for Stroke: Exeter Knockout Data Challenges Sigma-1 Story
Exeter data shows DMT inhibits stroke-related spreading depolarisations more effectively in sigma-1 knockout mice — challenging the prevailing mechanism.