Author
Stephen Page
Writer on DMT, ayahuasca, iboga and tryptamine research. LLB; incoming MSc in Psychedelics: Mind, Medicine and Culture, University of Exeter (2026)
ARDMT Field Notes
Strassman's IV DMT protocol: the dataset that still sets the dose
Rick Strassman's DMT studies were not the first to administer the compound to humans; that distinction belongs to the Hungarian chemist and psychiatrist Stephen Szára, who injected himself with it in 1956.
ARDMT Field Notes
DMT on VTA Ih-negative neurons: sex-dependent firing changes in reward circuitry
A group at the University of Exeter has turned its electrodes on a rather specific neuronal population: the Ih-negative cells of the ventral tegmental area.
ARDMT Field Notes
Manske to Szára: DMT's twenty-five years as a compound without a question
Manske's synthesis appeared in 1931, published in the Canadian Journal of Research, as part of a broader programme of work on tryptamine derivatives.
Foundations
What is the Sigma-1 Receptor?
A strange protein inside cells, why DMT binds to it, and the increasingly serious question of what that binding might mean.
Foundations
What is the Default Mode Network?
The brain regions that hum when you are not doing anything, the self that hums with them, and what psychedelics seem to do to the whole arrangement.
Foundations
Harmine and the MAOIs
Oral N,N-DMT, taken on its own, reaches the gut wall, encounters intestinal MAO-A, and is broken down before it can be absorbed. Almost none reaches the bloodstream. The body's protection against dietary amines is, in this case, doing exactly its job. Oral DMT is pharmacologically inactive.
ARDMT Field Notes
Lempel–Ziv complexity is the weakest correlate: Exeter's dose-dependent DMT EEG study
Lewis-Healey, Pallavicini, Cavanna and colleagues have now published, in the Journal of Cognitive Neuroscience, a dose-dependent EEG study of inhaled freebase DMT that carries a rather pointed conclusion:
Foundations
What is 5-MeO-DMT?
The shorthand version of why 5-MeO-DMT warrants its own primer: it is the DMT-family compound most likely to be confused with N,N-DMT and the one most likely to surprise readers
Foundations
What is Ayahuasca?
A plain-English orientation to ayahuasca — the plants, the pharmacology, the ceremony, the regional variations, the modern global story, and the open questions.
Understanding
What is DMT?
A plain-English orientation to DMT: the molecule, its forms, what it does, how it works, where it sits in UK law, and why the science is back open.
ARDMT Field Notes
DMT for Parkinson's: Sigma-1 Neuroprotection in a 6-OHDA Model
Calleja-Conde and Morales-García extend the Madrid group's DMT–sigma-1 neuroprotection case into a Parkinson's model. Suggestive, not yet definitive — but building.
ARDMT Field Notes
DMT shows neuroprotective effects in a Parkinson's rat model — a Madrid group extends its σ1R hypothesis
Could DMT protect dopamine neurons? A new preclinical study from Madrid says yes — at least in rats. Here's what the data show, what the σ1R–NRF2 mechanism implies, and why translation to human Parkinson's remains an open question.