Author
Stephen Page
Writer on DMT, ayahuasca, iboga and tryptamine research. LLB; incoming MSc in Psychedelics: Mind, Medicine and Culture, University of Exeter (2026)
ARDMT Field Notes
DMT EEG: Alpha Power Outperforms Lempel-Ziv Complexity (Timmermann)
Timmermann et al. test EEG correlates of the DMT experience: alpha power outperforms Lempel-Ziv complexity, the entropic-brain hypothesis's signature.
ARDMT Field Notes
DMT and Ayahuasca Clinical Trials: 2026 Pipeline Scoping Review
Stojanović et al. map every registered DMT and ayahuasca trial — and quantify how much of the field never publishes its results. Useful cartography.
Research
5-MeO-DMT Brain Connectivity in Awake Rats: Sex and Dose Effects
Cavallaro et al. (Ferris lab) map 5-MeO-DMT brain connectivity in awake rats — distinct dose and sex effects emerge in limbic and prefrontal circuits.
Research
DMT vs Ketamine: Equal on Depression, DMT Wins on Anxiety
De Sousa-Silva et al. compare DMT to S-ketamine in helpless mice: matched on depression, but DMT also produces anxiolysis. From the Natal ayahuasca group.
Research
Beckley Psytech's BPL-003: 5-MeO-DMT Without SSRI Washout
Beckley Psytech's BPL-003 trial gave intranasal 5-MeO-DMT to depressed patients still on SSRIs — no washout required. First proof-of-concept of its kind.
Research
Endogenous DMT: Not in Serotonin Terminals — Palner et al
Palner et al. find DMT is neither synthesised nor stored in serotonin terminals (rat). The endogenous DMT hypothesis narrows — but is not entirely buried.
Research
5-HT1A Blockade Potentiates DMT: Zahid, Strassman et al.
Zahid, Strassman et al. show that blocking 5-HT1A receptors potentiates DMT's subjective effects — first human evidence that the 5-HT1A 'brake' is real.
ARDMT Field Notes
DMT for Stroke: Exeter Knockout Data Challenges Sigma-1 Story
Exeter data shows DMT inhibits stroke-related spreading depolarisations more effectively in sigma-1 knockout mice — challenging the prevailing mechanism.
Research
DMT research: Top recent findings from 34 papers.
DMT research: top findings and the state of play A synthesis of 34 recent papers on DMT and its close analogue 5-MeO-DMT, written for a non-specialist professional audience. DMT is a small naturally occurring molecule, structurally similar to the neurotransmitter serotonin, that produ
ARDMT Field Notes
DMT for Substance Misuse: An Exeter/Imperial Meta-Analysis
A systematic review and meta-analysis examining whether DMT-based interventions can shift the needle on substance misuse has appeared in the Journal of Psychopharmacology, authored by a team spanning the University of Exeter and Imperial College London
Books
Bear's evening read.
Chapter One The Boy at the Edge The river was older than the village, and the village was older than anyone
Understanding
DMT an overview
From a forthcoming book — first chapter, free. ---