# ARDMT — Analysis + Research on DMT
> Evidence-led psychedelic research, translated. Field Notes, long-form essays on pharmacology, policy, and the cultures that grew these compounds — by Stephen Page.
Public Ghost content for AI and LLM tooling. Use `/llms-full.txt` for consolidated page and post context.
Append `.md` to any post or page URL to get the content in Markdown (for example, `/example-post.md`).

## Pages
- [About ARDMT](https://www.ardmt.com/about.md) - Stephen Page, founder and editor of ARDMT. I hold an LLB from the University of Sheffield and am undertaking the MSc in Psychedelics: Mind, Medicine, and Culture at the University of Exeter.
- [Library](https://www.ardmt.com/library.md) - Selection of books that are particularly relevant and read by the author of Ardmt whilst studying Psychedelics at masters level at Exeter Uni in UK.

## Posts
- [Everything I'm About to Tell You Is True.](https://www.ardmt.com/everything-im-about-to-tell-you-is-true.md) - The standard history of psychedelics is accurate, complete-sounding, and quietly doing work. Week one of the Exeter MSc, worked through as an argument rather than a syllabus.
- [When the Molecule Escapes the Plant: Iboga, Gabon and Who Benefits from Psychedelic Medicine](https://www.ardmt.com/when-the-molecule-escapes-the-plant-iboga-gabon-and-who-benefits-from-psychedelic-medicine.md) - Gabon has spent years trying to protect iboga from extraction. But ibogaine can already be produced from other African plants, while modern drug development can move further still — into synthetic analogues and digital information.
- [The Study That Became a Statute](https://www.ardmt.com/the-study-that-became-a-statute.md) - How a 30-person ibogaine study moved through veteran philanthropy, Stanford, Silicon Valley biotech and US state legislatures — and why the money is only part of the story.
- [Nichols Named the Experiment.](https://www.ardmt.com/nichols-named-the-experiment.md) - Eight Years Later, Someone Ran It. A follow-up to Endogenous DMT in Humans: A Critical Review of the State of the Evidence. That piece surveys the evidential structure; this one is about two results published five days apart, and what they do to it. David Nichols' 2018 review in the Journal of Psyc…
- [23 of 25](https://www.ardmt.com/23-of-25.md) - A deep dive into the magnesium-ibogaine treatment. So What Does a 12-Month Ibogaine Study Actually Show?
- [“You haven't taken psychedelics, so you can't understand.”](https://www.ardmt.com/you-havent-taken-psychedelics-so-you-cant-understand.md) - There's something obviously true about that. Someone who has taken DMT knows something about the experience that someone who hasn't simply doesn't. But how far does that authority extend? I've been reading Sarah Shortall's Psychedelic Drugs and the Problem of Experience (2014), and this was the ide…
- [The Same Evidence, Different Bryan Johnson](https://www.ardmt.com/the-same-evidence-different-bryan-johnson.md) - Bryan Johnson’s psychedelic claims seem to change depending on who is asking the question. On Theo Von’s podcast, psilocybin “legit is a longevity therapy.” In Johnson’s own more formal Blueprint write-up, the same experiment is described much more carefully: a high-dose p
- [Before the Molecule](https://www.ardmt.com/before-the-molecule.md) - The field's own meta-analysis found that therapy hours predict nothing in psychedelic trials. That is not a finding about therapy. It is a finding about the record.
- [When the Shit Hits the Bridge](https://www.ardmt.com/when-the-shit-hits-the-bridge.md) - Or Southern Water can burst three sewage mains in a week, deploy a fleet of tankers to manage the flows, and drive one of them ...
- [The Sensitive Period](https://www.ardmt.com/the-sensitive-period.md) - Two studies of psychedelics and new motherhood are underway. One raised $103 million. The other raised $3,200. They are not asking the same question.
- [Seventeen to One](https://www.ardmt.com/seventeen-to-one.md) - The field has begun to suspect that preparation is doing some of the work. Its consensus reporting standard gives the preparatory phase a single item.
- [Thirty-Seven Pages, Posted from Amsterdam](https://www.ardmt.com/thirty-seven-pages-posted-from-amsterdam.md) - In 1874 a farmer in upstate New York privately printed a pamphlet about anaesthesia and circulated it himself. Almost no original copies can now be found. One of them changed William James's mind — and Harvard turns out to hold the archive where the hunt should start.
- [Before the First Dose](https://www.ardmt.com/before-the-first-dose.md) - Twelve veterans with severe, treatment-resistant PTSD walked into a clinic in Ohio. Eleven weeks later, nine of them no longer met the diagnostic criteria for the condition that had, in most cases, defined a decade or more of their lives.
- [When Motherhood Feels Like a Trip: A Compelling Parallel That Hasn't Been Tested](https://www.ardmt.com/when-motherhood-feels-like-a-trip-a-compelling-parallel-that-hasnt-been-tested.md) - A mother says psilocybin made her calmer, more patient, better at the job. A Harvard thesis says her brain and the mushroom may be working on the same territory. The parallel is real. What it means is not yet known.
- [The Cerebellum and the Cactus](https://www.ardmt.com/the-cerebellum-and-the-cactus.md) - A new imaging study says mescaline does something to the cerebellum that no other psychedelic does. Half of that claim survives contact with the comparison papers. The connectivity half does not: the same laboratory had already reported cerebellar hyperconnectivity under LSD and psilocybin,
- [The Root It Refused](https://www.ardmt.com/the-root-it-refused.md) - In July 2026 the United States began paying to reopen the human ibogaine programme it walked away from thirty years ago. The science is real. The cardiac risk that stalled it is real.
- [Can Neural Cells Tell a Psychedelic from Its Sober Twin?](https://www.ardmt.com/can-neural-cells-tell-a-psychedelic-from-its-sober-twin.md) - DMT, LSD and psilocin made neural cells accumulate lactate. Their non-hallucinogenic look-alikes did not. Fuel, memory signal — or emergency brake?
- [Tonnage quantities](https://www.ardmt.com/tonnage-quantities.md) - Eli Lilly's 3.8 billion dollar move into psychedelic medicine is being described as an arrival. Its own history makes it look more like a return, and the drug it is buying carries a contested history of its own
- [The Room and the Record](https://www.ardmt.com/the-room-and-the-record.md) - There is a claim in psychedelic research that has been repeated for sixty years without being tied convincingly to a lasting biological measurement. It goes like this: the drug is not the whole story.
- [Can a therapist guide you somewhere they've never been?](https://www.ardmt.com/can-a-therapist-guide-you-somewhere-theyve-never-been.md) - The medicine opens the door. Whether the person sitting beside you can actually help you walk through it — and how you'd even know — is the question the field hasn't reckoned with yet.
- [The Instrument and the Threshold](https://www.ardmt.com/the-instrument-and-the-threshold.md) - This essay is about a narrow and unglamorous claim: that the field's standard method for answering the question cannot answer it. Not that the answer is one thing or the other.
- [The Litany Against Fear](https://www.ardmt.com/the-litany-against-fear.md) - In March of 2026, Christian Angermayer — biotech financier, founder and chairman of the psychedelic pharma company AtaiBeckley, largest shareholder in the same — published a short essay with a large claim.
- [Be Careful Not to Colonise Hyperspace](https://www.ardmt.com/be-careful-not-to-colonise-hyperspace.md) - The phrase surfaces, briefly, on a slide. Be careful not to colonise hyperspace. It is meant, I think, as a caution about attitude — about arriving in the DMT state with the postures of the conqueror rather than the
- [Holding the Door Open](https://www.ardmt.com/holding-the-door-open.md) - DMT is not exotic in the sense of being rare. It is one of the most widely distributed psychedelics in nature, produced by a great many plants and animals — and, importantly, by mammals, including, in trace amounts, us. (We will come back to that startling fact in Part VII.)
- [The Trained Bystander Paradox](https://www.ardmt.com/the-trained-bystander-paradox.md) - Should Voluntarily-Acquired Rescue Capability Generate a Limited Positive Duty in English Negligence Law?
- [The Toadstool Everyone Knows](https://www.ardmt.com/the-toadstool-everyone-knows.md) - Fly agaric is the most recognisable mushroom on Earth — Santa's colours, Alice's mushroom, Mario's power-up, the sacrament of the Vedas. Strip away the stories that aren't true and what remains is stranger than any of them:
- [The Net That Holds the Brake: How One Dose of Psilocybin Quiets the Brain's Drive Toward Reward](https://www.ardmt.com/the-net-that-holds-the-brake-how-one-dose-of-psilocybin-quiets-the-brains-drive-toward-reward.md) - A single injection, two days of silence, and then a measurable change in how much rats wanted what they used to want most — traced down to one inhibitory cell type wrapped in structural netting in the prefrontal cortex.
- [Who Owns a Molecule That Has Never Existed in Nature?](https://www.ardmt.com/who-owns-a-molecule-that-has-never-existed-in-nature.md) - In April 2026, a team at the Weizmann Institute of Science announced they had engineered a single, unglamorous relative of tobacco to produce five different natural psychedelics at once: psilocybin and psilocin, the mushroom compounds; DMT,
- [The Habit of the Universe](https://www.ardmt.com/the-habit-of-the-universe.md) - On morphic resonance, decapitated worms, lions that remember Rome, and what we might be doing when we take psychedelics
- [Notes from Haarlem](https://www.ardmt.com/notes-from-haarlem.md) - The question now is harder, and more interesting: how, exactly, are they to be used? What role does the subjective experience play? Are the non-hallucinogenic alternatives now in development the future of the field or a category error?
- [Tracking DMT's neural arc: time-resolved EEG at two doses](https://www.ardmt.com/tracking-dmts-neural-arc-time-resolved-eeg-at-two-doses.md) - Lewis-Healey E, Pallavicini C, Cavanna F, D'Amelio T, De La Fuente LA, Copa D, Müller S, Bruno N, Tagliazucchi E & Bekinschtein T. Journal of Cognitive Neuroscience
- [β-Carbolines and the MAO-A barrier: how ayahuasca makes oral DMT possible](https://www.ardmt.com/b-carbolines-and-the-mao-a-barrier-how-ayahuasca-makes-oral-dmt-possible.md) - In 1928, when Lewin catalogued mescaline among his Phantastica, he noted something curious about ayahuasca: the brew required two plants, not one. A single plant supplied the visions,
- [Why 0.4 mg/kg: Strassman's dose-finding logic and its thirty-year hold](https://www.ardmt.com/why-0-4-mg-kg-strassmans-dose-finding-logic-and-its-thirty-year-hold.md) - Strassman's dose-finding study, published in Archives of General Psychiatry in 1994, employed a double-blind design with four intravenous dose levels — 0.05, 0.1, 0.2, and 0.4 mg/kg of DMT fumarate
- [Deuterating DMT: how two neutrons reshape a pharmacokinetic profile](https://www.ardmt.com/deuterating-dmt-how-two-neutrons-reshape-a-pharmacokinetic-profile.md) - When Cybin Inc. filed its patent family around CYB003 — later redesignated SPL028 — the core chemical manoeuvre was, on its face, almost comically modest.
- [The Bell, the Clog, and the Gallows](https://www.ardmt.com/the-bell-the-clog-and-the-gallows.md) - The Mischievous Dog, taken across its full transmission, turns out to be less a stable moral tale than a record of successive interpretive needs. Each translator alters the object around the dog's neck
- [Which Ayahuasca?](https://www.ardmt.com/which-ayahuasca.md) - Ayahuasca is not one thing: one name, many brews, hidden variables, and a global habit of flattening complexity into a single word.
- [Shulgin's tryptamine notebooks: the cartography DMT research still navigates by](https://www.ardmt.com/shulgins-tryptamine-notebooks-the-cartography-dmt-research-still-navigates-by.md) - The relevance of Shulgin's tryptamine work to present-day DMT research is not merely historical. Several active lines of enquiry trace their intellectual ancestry directly to his structure-activity observations.
- [Speech biomarkers after 5-MeO-DMT: can how you talk reveal what changed?](https://www.ardmt.com/speech-biomarkers-after-5-meo-dmt-can-how-you-talk-reveal-what-changed.md) - Kuc, McAlpine, Sellers, Blackburne, Lametti, and Skipper, writing in the Journal of Psychopharmacology, report on what they term "speech markers of psychological change"
- [Ayahuasca is not one thing](https://www.ardmt.com/ayahuasca-is-not-one-thing.md) - yahuasca' denotes a variable ethnobotanical category, not a single brew. The variation matters for ceremony, chemistry, consent, and clinical research.
- [Machine learning validates indigenous folk taxonomy of the ayahuasca vine](https://www.ardmt.com/machine-learning-validates-indigenous-folk-taxonomy-of-the-ayahuasca-vine-2.md) - A machine learning study quietly validates indigenous taxonomy of Banisteriopsis caapi — and raises a harder question about what counts as scientific knowledge.
- [The Trouble with Supernormal Stimuli.](https://www.ardmt.com/the-trouble-with-supernormal-stimuli.md) - Wide vintage-style ARDMT Field Notes comic strip titled “The Trouble with Supernormal Stimuli,” showing male Australian jewel beetles mistaking glossy brown beer bottles for females, illustrating how exaggerated artificial cues can override natural mating signals and create an evolutionary trap.
- [The Case of the Vanishing Molecule](https://www.ardmt.com/the-case-of-the-vanishing-molecule.md) - Wide vintage-style ARDMT Field Notes comic strip titled “The Case of the Vanishing Molecule,” showing the scientific history of endogenous DMT from Julius Axelrod’s 1961 INMT enzyme discovery through inconsistent transmethylation-era findings, Borjigin’s rat brain studies, and modern
- [The Compound That Forgot to be Interesting.](https://www.ardmt.com/the-compound-that-forgot-to-be-interesting.md) - The Compound That Forgot to Be Interesting — a field note on timing, context, and rejected purchase orders. In 1931 the Canadian chemist Richard H. F. Manske first synthesised N,N-dimethyltryptamine and entered it into a table of tryptamine derivatives without ever suspecting what it would become.
- [Endogenous DMT from Axelrod to Borjigin: what sixty years have settled and what they have not](https://www.ardmt.com/endogenous-dmt-from-axelrod-to-borjigin-what-sixty-years-have-settled-and-what-they-have-not.md) - The story begins, as so many stories in psychedelic pharmacology do, with Julius Axelrod. In 1961, working at the National Institute of Mental Health, Axelrod demonstrated that rabbit lung tissue contained an enzyme capable of methylating tryptamine to form DMT.
- [Extended-state DMT infusion: three decades almost-but-not-quite attempted](https://www.ardmt.com/extended-state-dmt-infusion-three-decades-almost-but-not-quite-attempted.md) - There is something faintly poignant about the extended-state protocol's career: pharmacokinetically straightforward, clinically demanding, ethically complex, and philosophically loaded, all at once.
- [DMT in a Parkinson's model: Madrid group returns with fuller claims](https://www.ardmt.com/dmt-in-a-parkinsons-model-madrid-group-returns-with-fuller-claims.md) - The Madrid group — Morales-García, López-Moreno, Calleja-Conde, and colleagues — return to Experimental Neurology with what appears to be their most developed account yet of DMT's neuroprotective potential in a preclinical model of Parkinson's disease.
- [Strassman's IV DMT protocol: the dataset that still sets the dose](https://www.ardmt.com/strassmans-iv-dmt-protocol-the-dataset-that-still-sets-the-dose.md) - Rick Strassman's DMT studies were not the first to administer the compound to humans; that distinction belongs to the Hungarian chemist and psychiatrist Stephen Szára, who injected himself with it in 1956.
- [DMT on VTA Ih-negative neurons: sex-dependent firing changes in reward circuitry](https://www.ardmt.com/dmt-on-vta-ih-negative-neurons-sex-dependent-firing-changes-in-reward-circuitry.md) - A group at the University of Exeter has turned its electrodes on a rather specific neuronal population: the Ih-negative cells of the ventral tegmental area.
- [Manske to Szára: DMT's twenty-five years as a compound without a question](https://www.ardmt.com/manske-to-szara-dmts-twenty-five-years-as-a-compound-without-a-question.md) - Manske's synthesis appeared in 1931, published in the Canadian Journal of Research, as part of a broader programme of work on tryptamine derivatives.
- [What is the Sigma-1 Receptor?](https://www.ardmt.com/what-is-the-sigma-1-receptor.md) - A strange protein inside cells, why DMT binds to it, and the increasingly serious question of what that binding might mean.
- [What is the Default Mode Network?](https://www.ardmt.com/what-is-the-default-mode-network.md) - The brain regions that hum when you are not doing anything, the self that hums with them, and what psychedelics seem to do to the whole arrangement.
- [Harmine and the MAOIs](https://www.ardmt.com/harmine-and-the-maois.md) - Oral N,N-DMT, taken on its own, reaches the gut wall, encounters intestinal MAO-A, and is broken down before it can be absorbed. Almost none reaches the bloodstream. The body's protection against dietary amines is, in this case, doing exactly its job. Oral DMT is pharmacologically inactive.
- [Lempel–Ziv complexity is the weakest correlate: Exeter's dose-dependent DMT EEG study](https://www.ardmt.com/lempel-ziv-complexity-is-the-weakest-correlate-exeters-dose-dependent-dmt-eeg-study.md) - Lewis-Healey, Pallavicini, Cavanna and colleagues have now published, in the Journal of Cognitive Neuroscience, a dose-dependent EEG study of inhaled freebase DMT that carries a rather pointed conclusion:
- [What is 5-MeO-DMT?](https://www.ardmt.com/what-is-5-meo-dmt.md) - The shorthand version of why 5-MeO-DMT warrants its own primer: it is the DMT-family compound most likely to be confused with N,N-DMT and the one most likely to surprise readers
- [What is Ayahuasca?](https://www.ardmt.com/what-is-ayahuasca.md) - A plain-English orientation to ayahuasca — the plants, the pharmacology, the ceremony, the regional variations, the modern global story, and the open questions.
- [What is DMT?](https://www.ardmt.com/what-is-dmt.md) - A plain-English orientation to DMT: the molecule, its forms, what it does, how it works, where it sits in UK law, and why the science is back open.
- [DMT for Parkinson's: Sigma-1 Neuroprotection in a 6-OHDA Model](https://www.ardmt.com/dmt-for-parkinsons-sigma-1-neuroprotection-in-a-6-ohda-model.md) - Calleja-Conde and Morales-García extend the Madrid group's DMT–sigma-1 neuroprotection case into a Parkinson's model. Suggestive, not yet definitive — but building.
- [DMT shows neuroprotective effects in a Parkinson's rat model — a Madrid group extends its σ1R hypothesis](https://www.ardmt.com/dmt-shows-neuroprotective-effects-in-a-parkinsons-rat-model-a-madrid-group-extends-its-s1r-hypothesis.md) - Could DMT protect dopamine neurons? A new preclinical study from Madrid says yes — at least in rats. Here's what the data show, what the σ1R–NRF2 mechanism implies, and why translation to human Parkinson's remains an open question.
- [Ayahuasca Alkaloids in Hair: A New Long-Window Exposure Biomarker](https://www.ardmt.com/ayahuasca-alkaloids-in-hair-a-new-long-window-exposure-biomarker.md) - Santos et al. validate a hair-analysis method for DMT and β-carbolines — turning a single strand into a months-long record of ayahuasca exposure.
- [The Committee on Extraordinary Claims. Part 1](https://www.ardmt.com/the-committee-on-extraordinary-claims-part-1.md) - The margin is where the medieval scribe drew dragons and pulled faces while the main text held forth on theology. This is that margin.
- [Szára's 1956 self-experiment: the Budapest dose that launched DMT research](https://www.ardmt.com/szaras-1956-self-experiment-the-budapest-dose-that-launched-dmt-research.md) - Cold War Hungary, 1956: Stephen Szára couldn't get LSD, so he made DMT and dosed himself. Modern psychedelic research began that afternoon.
- [Endogenous DMT in Humans: A Critical Review of the State of the Evidence](https://www.ardmt.com/endogenous-dmt-critical-review.md) - A critical review of the evidence, the inferences drawn from it, and the limits of cross-species extrapolation: detection, biosynthesis, function and psychoactive sufficiency .
- [DEEP DIVE #1 Five Hundred Million Years Apart, Touching Through the Glass: The Octopus, MDMA, and the Deep Chemistry of Social Connection](https://www.ardmt.com/deep-dive-1-five-hundred-million-years-apart-touching-through-the-glass-the-octopus-mdma-and-the-deep-chemistry-of-social-connection.md) - In 2018, Eric Edsinger and Gül Dölen published a short paper in Current Biology that posed an apparently absurd question: what happens when you give MDMA to an octopus?
- [Can Halogenated DMT Analogues Be Non-Hallucinogenic? G-Protein Bias](https://www.ardmt.com/can-halogenated-dmt-analogues-be-non-hallucinogenic-g-protein-bias.md) - A preprint shows 2-chloro and 2-bromo DMT analogues display G-protein bias at 5-HT2A — relevant to the hunt for non-hallucinogenic psychedelics.
- [Long-Term Ayahuasca: Personality Shifts, Cognition Intact (Bouso)](https://www.ardmt.com/long-term-ayahuasca-personality-shifts-cognition-intact-bouso.md) - Bouso compares chronic ayahuasca users with cannabis users and non-users: personality differs across groups, cognitive function is spared.
- [Ayahuasca vs Meditation: Two Routes to Ego Dissolution?](https://www.ardmt.com/ayahuasca-vs-meditation-two-routes-to-ego-dissolution.md) - Arqueros et al. compare hypo-egoic features in ayahuasca users and long-term meditators — testing whether pharmacology and contemplation reach the same place.
- [2-Halogenated Tryptamines: How One Atom Reshapes DMT Pharmacology](https://www.ardmt.com/2-halogenated-tryptamines-how-one-atom-reshapes-dmt-pharmacology.md) - Von Salm, McCorvy and Baumann profile 2-halogenated tryptamines: halogen choice at the 2-position reshapes 5-HT receptor selectivity and signalling bias.
- [UCL's UNITy Trial: Can DMT Disrupt Alcohol Memory Reconsolidation?](https://www.ardmt.com/ucls-unity-trial-can-dmt-disrupt-alcohol-memory-reconsolidation.md) - UCL's UNITy trial pairs IV DMT with alcohol memory reactivation in heavy drinkers — testing whether DMT plasticity can rewrite addiction memories.
- [DMT EEG: Alpha Power Outperforms Lempel-Ziv Complexity (Timmermann)](https://www.ardmt.com/dmt-eeg-alpha-power-outperforms-lempel-ziv-complexity-timmermann.md) - Timmermann et al. test EEG correlates of the DMT experience: alpha power outperforms Lempel-Ziv complexity, the entropic-brain hypothesis's signature.
- [DMT and Ayahuasca Clinical Trials: 2026 Pipeline Scoping Review](https://www.ardmt.com/dmt-and-ayahuasca-clinical-trials-2026-pipeline-scoping-review.md) - Stojanović et al. map every registered DMT and ayahuasca trial — and quantify how much of the field never publishes its results. Useful cartography.
- [5-MeO-DMT Brain Connectivity in Awake Rats: Sex and Dose Effects](https://www.ardmt.com/5-meo-dmt-brain-connectivity-in-awake-rats-sex-and-dose-effects.md) - Cavallaro et al. (Ferris lab) map 5-MeO-DMT brain connectivity in awake rats — distinct dose and sex effects emerge in limbic and prefrontal circuits.
- [DMT vs Ketamine: Equal on Depression, DMT Wins on Anxiety](https://www.ardmt.com/dmt-vs-ketamine-equal-on-depression-dmt-wins-on-anxiety.md) - De Sousa-Silva et al. compare DMT to S-ketamine in helpless mice: matched on depression, but DMT also produces anxiolysis. From the Natal ayahuasca group.
- [Beckley Psytech's BPL-003: 5-MeO-DMT Without SSRI Washout](https://www.ardmt.com/beckley-psytechs-bpl-003-5-meo-dmt-without-ssri-washout.md) - Beckley Psytech's BPL-003 trial gave intranasal 5-MeO-DMT to depressed patients still on SSRIs — no washout required. First proof-of-concept of its kind.
- [Endogenous DMT: Not in Serotonin Terminals — Palner et al](https://www.ardmt.com/endogenous-dmt-not-in-serotonin-terminals-palner-et-al.md) - Palner et al. find DMT is neither synthesised nor stored in serotonin terminals (rat). The endogenous DMT hypothesis narrows — but is not entirely buried.
- [5-HT1A Blockade Potentiates DMT: Zahid, Strassman et al.](https://www.ardmt.com/5-ht1a-blockade-potentiates-dmt-zahid-strassman-et-al.md) - Zahid, Strassman et al. show that blocking 5-HT1A receptors potentiates DMT's subjective effects — first human evidence that the 5-HT1A 'brake' is real.
- [DMT for Stroke: Exeter Knockout Data Challenges Sigma-1 Story](https://www.ardmt.com/dmt-for-stroke-exeter-knockout-data-challenges-sigma-1-story.md) - Exeter data shows DMT inhibits stroke-related spreading depolarisations more effectively in sigma-1 knockout mice — challenging the prevailing mechanism.
- [DMT research: Top recent findings from 34 papers.](https://www.ardmt.com/dmt-research-top-recent-findings-from-34-papers.md) - DMT research: top findings and the state of play A synthesis of 34 recent papers on DMT and its close analogue 5-MeO-DMT, written for a non-specialist professional audience. DMT is a small naturally occurring molecule, structurally similar to the neurotransmitter serotonin, that produ
- [DMT for Substance Misuse: An Exeter/Imperial Meta-Analysis](https://www.ardmt.com/dmt-substance-misuse-meta-analysis.md) - A systematic review and meta-analysis examining whether DMT-based interventions can shift the needle on substance misuse has appeared in the Journal of Psychopharmacology, authored by a team spanning the University of Exeter and Imperial College London
- [Bear's evening read.](https://www.ardmt.com/bears-evening-read.md) - Chapter One The Boy at the Edge The river was older than the village, and the village was older than anyone
- [DMT an overview](https://www.ardmt.com/dmt-an-overview.md) - From a forthcoming book — first chapter, free. ---
- [SPL028 Cybin 2024](https://www.ardmt.com/spl028-cybin-2024.md) - What a careful read of the SPL028 Phase 1 synopsis tells us about deuteration....

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